BPC-157

H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH

Key Benefits

Gut Health

Stabilizes the gut-brain axis, enhancing the expression of growth hormone receptors, and reducing intestinal inflammation through the downregulation of pro-inflammatory cytokines, thereby ameliorating conditions such as inflammatory bowel disease and leaky gut syndrome through the restoration of intestinal integrity and mucosal healing.

Muscle Growth

Augmentes the expression of myogenic regulatory factors such as MyoD and MRF4, enhancing satellite cell proliferation, and modulates the TGF-β signaling pathway, which collectively contribute to myofiber regeneration, reduction of fibrosis, and improvement in muscle contractility post-injury.

Accelerated Healing

Modulation of the SDF-1/CXCR4 axis, and enhancement of the EGR1 gene, leading to improved angiogenesis, tissue regeneration, and cellular migration, while concurrently attenuating pro-inflammatory cytokine activity and fostering extracellular matrix remodeling in injured tissues.

Neuro Regenerative

Enhances neural growth factor synthesis, modulating the Akt/ERK pathway, and upregulating BDNF and FGF-2 expression, which collectively contribute to the proliferation and differentiation of neural progenitor cells, and the fortification of synaptic plasticity and neuronal connectivity in neurodegenerative and traumatic brain injury contexts.

Biologic Description

Body Protection Compound 157 (BPC-157) is a peptide composed of 15 amino acids, which has become a subject of interest in the field of regenerative medicine and injury recovery. Although its exact origin is debated, it's generally believed to be derived from a protein found in the stomach.

BPC-157's potential therapeutic applications are rooted in its diverse biological mechanisms. Primarily, it's known for promoting angiogenesis, the formation of new blood vessels from existing ones. This process is critical in healing as it ensures an adequate blood supply to injured or damaged tissues, facilitating the delivery of essential nutrients and oxygen required for repair.

The peptide also plays a significant role in tissue repair and regeneration. It stimulates the growth and survival of various cell types, including tendon cells, muscle cells, and ligaments. This ability to promote cell survival and migration is key to its regenerative properties, accelerating the healing process in injured tissues.

Another notable aspect of BPC-157's action is its anti-inflammatory properties. Inflammation is a natural response to injury, but excessive inflammation can hinder the healing process and cause pain. BPC-157 may mitigate these effects by modulating various inflammatory mediators, thereby reducing swelling and discomfort associated with tissue damage.

Beyond its effects on physical tissues, BPC-157 is also believed to influence the gut-brain axis, a bidirectional communication network between the gastrointestinal tract and the central nervous system. This has implications for both neurological and digestive health, including potential neuroprotective effects and improvements in cognitive functions observed in animal models.

The peptide's influence extends to nitric oxide synthesis, which is vital for a range of physiological processes like vascular dilation, immune responses, and neurotransmission. By promoting nitric oxide synthesis, BPC-157 may play a role in improving blood flow and aiding in the body's natural healing and defense mechanisms.

Additionally, BPC-157 is thought to stimulate the synthesis of growth factors, which are essential for tissue growth and maintenance. Growth factors influence cellular processes such as proliferation, differentiation, and survival, and their stimulation by BPC-157 could be a cornerstone in its healing properties.

Finally, BPC-157 may affect neurotransmission, particularly in the dopaminergic and serotonergic systems. These systems are crucial for mood regulation and cognitive functions, suggesting that BPC-157 might have broader implications beyond tissue repair and regeneration.

Dosage Guidelines

A typical amount of BPC-157 for daily use is around 250mcg, administered through an intramuscular injection. Researchers often follow a guideline of 2-4 micrograms per kilogram of body weight.

250-500mcg

Daily

4-8 Weeks

Side Effects

Scientific documentation on BPC-157's side effects in humans is scarce, with most information derived from preclinical studies and anecdotal human use.

Side effects commonly reported are associated with its typical administration methods - intramuscular or subcutaneous injection. These include redness, swelling, itching, or skin reactions at the injection site, usually not severe.

Being a gastric peptide, BPC-157 may cause digestive issues like nausea, diarrhea, changes in appetite, gas, and bloating. Dizziness and headaches have also been noted.

As BPC-157 is pro-angiogenic, there's a theoretical risk it might promote cancer growth, but the extent of this risk remains unclear.

No comprehensive human studies have conclusively detailed BPC-157 side effects. Therefore, its administration and dosing should be overseen by researchers knowledgeable in its use.

Researchers should also consider BPC-157's effects on erectile dysfunction.

References:

Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle
This paper reviews the healing potential of BPC 157 therapy in various muscle disabilities and weaknesses, including its impact on heart and smooth muscle functioning.

Published: Dec 2022

Stable Gastric Pentadecapeptide BPC 157 and Wound Healing
This study focuses on the healing capabilities of BPC 157 in different types of wounds, including skin wounds, deep burns, and diabetic ulcers, suggesting its general applicability to other tissues healing.

Published: Jun 2021

Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing

This paper critically reviews the use of BPC 157 in the healing and functional restoration of soft tissue damage, especially focusing on tendon, ligament, and skeletal muscle healing.

Published: Mar 2019

BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing

This article discusses BPC 157's effectiveness compared to standard angiogenic growth factors in healing the gastrointestinal tract, tendon, ligament, muscle, and bone injuries.

Published: Sep 2018